12/25/2023 0 Comments Gram negative bacteria listincreased rates of tendinitis, with special predilection for the Achilles tendon.inhibit early fracture healing through toxic effects on chondrocytes.blocks DNA replication via inhibition of DNA gyrase.same mechanicsm of action as beta-lactam antibiotics (such as penicillins).peptidoglycan layer is important for cell wall structural integrity.does so through competitive inhibition on PCB (penicllin binding proteins).disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.interferes with bacterial cell wall synthesis.for inducible clindamycin resistance in Staph and beta hemolytic Strep.erm gene confer inducible resistance to MLS (macrolide lincosamide streptogranin) agents via methylation of 23s rRNA.Altered peptidoglycan subunit (altered D-alanyl-D-alanine of NAM/NAG-peptide).confers resistance to erythromycin and tetracycline.provides an environment where offending bacteria can multiply safe from the hoste immune system.confers resistance to tetracyclines, quinolones, trimethoprim and β lactam antibiotics.SCCmec type IV has less genetic elements and is specific to CA-MRSA, making CA-MRSA less multi-drug resistant.confers resistance to methicillin, oxacillin, nafcillin.PBP2a has reduced affinity for antibiotics.a bacterial gene encoding a penicillin-binding protein (PBP2a).carried by Staphylococcal cassette chromosome (SCCmec) mobile genetic unit.clavulanic acid in amoxicillin-clavulanate (Augmentin) coli, Staph epidermidis, Pseudomonas aeruginosa, Klebsiella pneumoniae Bacteria develop ability to hydrolyze these drugs using β lactamase.His one great achievement is being the father of three amazing children. He is one of the founders of the FOAM movement (Free Open-Access Medical education) and is co-creator of , the RAGE podcast, the Resuscitology course, and the SMACC conference. He created the ‘Critically Ill Airway’ course and teaches on numerous courses around the world. He coordinates the Alfred ICU’s education and simulation programmes and runs the unit’s education website, INTENSIVE. He is actively involved in in using translational simulation to improve patient care and the design of processes and systems at Alfred Health. He has completed fellowship training in both intensive care medicine and emergency medicine, as well as post-graduate training in biochemistry, clinical toxicology, clinical epidemiology, and health professional education. He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives.Īfter finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. He is on the Board of Directors for the Intensive Care Foundation and is a First Part Examiner for the College of Intensive Care Medicine. He is also a Clinical Adjunct Associate Professor at Monash University. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. Piperacillin-tazobactam 4.5g Q8hrly, second or third generation cephalosporins, fluroquinolones (ciprofloxacin, moxifloxacin)Īzithromycin or erythromycin, ceftriaxone, ciprofloxacinĬhris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. > resistance to imipenem can develop during treatment (5) fluroquinolones: ciprofloxacin, moxifloxacin mild/ moderate: ceftazidine + co-trimoxazole.co-trimoxazole 10mg/kg of sulphamethoxazole, ciprofloxacin.enterocolitica: fluoroquinolone, co-trimoxazole 10mg/kg of sulphamethoxazole.pestis: streptomycin, gentamycin, doxycycline.fluroquinolones: ciprofloxacin, moxifloxacin.> only 90% coverage with penicillin & amoxicillin > not as much cover with amoxicillin-clavulnate, trimethoprim and co-trimoxazole > amoxicillin and penicillin = waste of time nitrofurantoin 100mg QID PO (5-7mg/kg/day).tobramycin 3-5mg/kg/day in 3 divided doses -> monitor.gentamicin 3-5mg/kg LD -> titrate to trough.> aminoglycosides are good agents (gentamicin, tobramycin, amikacin, streptomycin) co-trimoxazole 10mg/kg of sulphamethoxazole.second or third generation cephalosporin.gonorrhoea: piperacillin-tazobactam 4.5g Q8hrly, ceftriaxone.
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